PACK: Profile Analysis using Clustering and Kurtosis to find molecular classifiers in cancer
Author(s) -
Andrew E. Teschendorff,
Ali Naderi,
Nuno L. BarbosaMorais,
Carlos Caldas
Publication year - 2006
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btl174
Subject(s) - feature selection , false discovery rate , computer science , pattern recognition (psychology) , kurtosis , outlier , false positive paradox , artificial intelligence , cluster analysis , breast cancer , data mining , computational biology , cancer , mathematics , biology , statistics , gene , biochemistry , genetics
Elucidating the molecular taxonomy of cancers and finding biological and clinical markers from microarray experiments is problematic due to the large number of variables being measured. Feature selection methods that can identify relevant classifiers or that can remove likely false positives prior to supervised analysis are therefore desirable.
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