ALTree: association detection and localization of susceptibility sites using haplotype phylogenetic trees | Zendy

Claire Bardel | Zendy; Vincent Danjean | Zendy; Emmanuelle Génin | Zendy

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ALTree: association detection and localization of susceptibility sites using haplotype phylogenetic trees

Author(s) -

Claire Bardel,

Vincent Danjean,

Emmanuelle Génin

Publication year - 2006

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btl131

Subject(s) - phylogenetic tree , haplotype , association (psychology) , genetics , tree (set theory) , phylogenetics , evolutionary biology , biology , computational biology , gene , combinatorics , mathematics , allele , psychology , psychotherapist

Finding the genes involved in complex diseases susceptibility and among those genes, localizing the variant sites explaining this susceptibility is a major goal of genetic epidemiology. In this context, haplotypic methods that use the joint information on several markers may be of particular interest. When the number of haplotypes is large, a grouping may be required. Phylogenetic trees allow such groupings of haplotypes based on their evolutionary history and may help in the detection and localization of disease susceptibility sites. In this paper, we present a new software to perform phylogeny-based association and localization analysis.

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