HTS-Corrector: software for the statistical analysis and correction of experimental high-throughput screening data | Zendy

Vladimir Makarenkov | Zendy; Dmytro Kevorkov | Zendy; Pablo Zentilli | Zendy; Andrei Gagarin | Zendy; Nathalie Malo | Zendy; Robert Nadon | Zendy

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HTS-Corrector: software for the statistical analysis and correction of experimental high-throughput screening data

Author(s) -

Vladimir Makarenkov,

Dmytro Kevorkov,

Pablo Zentilli,

Andrei Gagarin,

Nathalie Malo,

Robert Nadon

Publication year - 2006

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btl126

Subject(s) - computer science , software , throughput , error detection and correction , data mining , raw data , reliability engineering , computer engineering , algorithm , operating system , programming language , engineering , wireless

High-throughput screening (HTS) plays a central role in modern drug discovery, allowing for testing of >100,000 compounds per screen. The aim of our work was to develop and implement methods for minimizing the impact of systematic error in the analysis of HTS data. To the best of our knowledge, two new data correction methods included in HTS-Corrector are not available in any existing commercial software or freeware.

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