Predicting protein interaction sites: binding hot-spots in protein–protein and protein–ligand interfaces | Zendy

Nicholas J. Burgoyne | Zendy; Richard M. Jackson | Zendy

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Predicting protein interaction sites: binding hot-spots in protein–protein and protein–ligand interfaces

Author(s) -

Nicholas J. Burgoyne,

Richard M. Jackson

Publication year - 2006

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btl079

Subject(s) - van der waals force , ligand (biochemistry) , protein–protein interaction , plasma protein binding , chemistry , surface protein , electrostatics , protein ligand , protein structure , sequence (biology) , biophysics , chemical physics , crystallography , biology , biochemistry , molecule , receptor , organic chemistry , virology

Protein assemblies are currently poorly represented in structural databases and their structural elucidation is a key goal in biology. Here we analyse clefts in protein surfaces, likely to correspond to binding 'hot-spots', and rank them according to sequence conservation and simple measures of physical properties including hydrophobicity, desolvation, electrostatic and van der Waals potentials, to predict which are involved in binding in the native complex.

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