Detection of a tandem BRCT in Nbs1 and Xrs2 with functional implications in the DNA damage response | Zendy

E. Becker | Zendy; Vincent Meyer | Zendy; Hocine Madaoui | Zendy; Raphaël Guérois | Zendy

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Detection of a tandem BRCT in Nbs1 and Xrs2 with functional implications in the DNA damage response

Author(s) -

E. Becker,

Vincent Meyer,

Hocine Madaoui,

Raphaël Guérois

Publication year - 2006

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btl075

Subject(s) - nijmegen breakage syndrome , rad50 , biology , computational biology , genetics , tandem repeat , dna repair , dna , saccharomyces cerevisiae , gene , dna damage , genome , dna binding protein , transcription factor , ataxia telangiectasia

Human Nbs1 and its homolog Xrs2 in Saccharomyces cerevisiae are part of the conserved MRN complex (MRX in yeast) which plays a crucial role in maintaining genomic stability. NBS1 corresponds to the gene mutated in the Nijmegen breakage syndrome (NBS) known as a radiation hyper-sensitive disease. Despite the conservation and the importance of the MRN complex, the high sequence divergence between Nbs1 and Xrs2 precluded the identification of common domains downstream of the N-terminal Fork-Head Associated (FHA) domain.

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