Matched-pairs tests of homogeneity with applications to homologous nucleotide sequences | Zendy

Faisal Ababneh | Zendy; Lars S. Jermiin | Zendy; Chunsheng Ma | Zendy; John Robinson | Zendy

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Matched-pairs tests of homogeneity with applications to homologous nucleotide sequences

Author(s) -

Faisal Ababneh,

Lars S. Jermiin,

Chunsheng Ma,

John Robinson

Publication year - 2006

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btl064

Subject(s) - phylogenetic tree , computer science , computational biology , biology , genetics , sequence alignment , mathematics , gene , peptide sequence

Most phylogenetic methods assume that the sequences of nucleotides or amino acids have evolved under stationary, reversible and homogeneous conditions. When these assumptions are violated by the data, there is an increased probability of errors in the phylogenetic estimates. Methods to examine aligned sequences for these violations are available, but they are rarely used, possibly because they are not widely known or because they are poorly understood.

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