Thermodynamics of RNA–RNA binding | Zendy

Ulrike Mückstein | Zendy; Hakim Tafer | Zendy; Jörg Hackermüller | Zendy; Stephan Wolf | Zendy; Peter F. Stadler | Zendy; Ivo L. Hofacker | Zendy

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Thermodynamics of RNA–RNA binding

Author(s) -

Ulrike Mückstein,

Hakim Tafer,

Jörg Hackermüller,

Stephan Wolf,

Peter F. Stadler,

Ivo L. Hofacker

Publication year - 2006

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btl024

Subject(s) - rna , rna interference , computational biology , messenger rna , partition function (quantum field theory) , physics , binding site , chemistry , biophysics , biology , biochemistry , gene , quantum mechanics

Reliable prediction of RNA-RNA binding energies is crucial, e.g. for the understanding on RNAi, microRNA-mRNA binding and antisense interactions. The thermodynamics of such RNA-RNA interactions can be understood as the sum of two energy contributions: (1) the energy necessary to 'open' the binding site and (2) the energy gained from hybridization.

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