Open AccessMaximum likelihood estimates of allele frequencies and error rates from samples of related individuals by gene counting
Author(s) -
Alun Thomas,
Nicola J. Camp
Publication year - 2006
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/btk049
Subject(s) - allele , statistics , allele frequency , genetics , maximum likelihood , gene , biology , mathematics
Graphical modeling is used to extend the gene counting method to compute maximum likelihood estimates of allele frequencies for samples of individuals related in extended pedigrees. Genotypes may be missing or partially observed, and error rates can be simultaneously estimated.
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