A simple method to predict protein-binding from aligned sequences—application to MHC superfamily and β2-microglobulin | Zendy

Élodie Duprat | Zendy; MariePaule Lefranc | Zendy; Olivier Gascuel | Zendy

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A simple method to predict protein-binding from aligned sequences—application to MHC superfamily and β2-microglobulin

Author(s) -

Élodie Duprat,

MariePaule Lefranc,

Olivier Gascuel

Publication year - 2005

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bti826

Subject(s) - beta 2 microglobulin , superfamily , simple (philosophy) , major histocompatibility complex , computational biology , computer science , biology , genetics , immunology , antigen , gene , philosophy , epistemology

The MHC superfamily (MhcSF) consists of immune system MHC class I (MHC-I) proteins, along with proteins with a MHC-I-like structure that are involved in a large variety of biological processes. beta2-Microglobulin (B2M) non-covalent binding to MHC-I proteins is required for their surface expression and function, whereas MHC-I-like proteins interact, or not, with B2M. This study was designed to predict B2M binding (or non-binding) of newly identified MhcSF proteins, in order to decipher their function, understand the molecular recognition mechanisms and identify deleterious mutations. IMGT standardization of MhcSF protein domains provides a unique numbering of the multiple alignment positions, and conditions to develop such predictive tool.

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