Equivalent binding sites reveal convergently evolved interaction motifs | Zendy

Andreas Henschel | Zendy; Wankyu Kim | Zendy; Michael Schroeder | Zendy

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Equivalent binding sites reveal convergently evolved interaction motifs

Author(s) -

Andreas Henschel,

Wankyu Kim,

Michael Schroeder

Publication year - 2005

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bti782

Subject(s) - protein–protein interaction , biology , computational biology , structural motif , binding site , proteases , genetics , enzyme , biochemistry

Much research has been devoted to the characterization of interaction interfaces found in complexes with known structure. In this context, the interactions of non-homologous domains at equivalent binding sites are of particular interest, as they can reveal convergently evolved interface motifs. Such motifs are an important source of information to formulate rules for interaction specificity and to design ligands based on the common features shared among diverse partners.

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