Motif-based protein ranking by network propagation | Zendy

Rui Kuang | Zendy; Jason Weston | Zendy; William Stafford Noble | Zendy; Christina Leslie | Zendy

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Motif-based protein ranking by network propagation

Author(s) -

Rui Kuang,

Jason Weston,

William Stafford Noble,

Christina Leslie

Publication year - 2005

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bti608

Subject(s) - pairwise comparison , motif (music) , structural motif , computer science , computational biology , sequence motif , homology (biology) , conserved sequence , sequence alignment , artificial intelligence , biology , pattern recognition (psychology) , genetics , peptide sequence , gene , physics , biochemistry , acoustics

Sequence similarity often suggests evolutionary relationships between protein sequences that can be important for inferring similarity of structure or function. The most widely-used pairwise sequence comparison algorithms for homology detection, such as BLAST and PSI-BLAST, often fail to detect less conserved remotely-related targets.

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