GenColors: accelerated comparative analysis and annotation of prokaryotic genomes at various stages of completeness
Author(s) -
Alessandro Romualdi,
Roman A. Siddiqui,
Gernot Glöckner,
Rüdiger Lehmann,
Jürgen Sühnel
Publication year - 2005
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/bti606
Subject(s) - genome , annotation , genbank , genome project , computer science , genome browser , computational biology , reference genome , biology , gene , genomics , genetics , artificial intelligence
GenColors is a new web-based software/database system aimed at an improved and accelerated annotation of prokaryotic genomes, considering information on related genomes and making extensive use of genome comparison. It offers a seamless integration of data from ongoing sequencing projects and annotated genomic sequences obtained from GenBank. The genome comparison tools determine, for example, best-bidirectional hits, gene conservation, syntenies and gene core sets. Swiss-Prot/TrEMBL hits allow annotations in an effective manner. To further support the annotation base-specific quality data can also be displayed if available. With GenColors dedicated genome browsers containing a group of related genomes can be easily set up and maintained. It has been efficiently used for Borrelia garinii and is currently applied to various ongoing genome projects.
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