A multicellular systems biology model predicts epidermal morphology, kinetics and Ca2+ flow | Zendy

Niels Grabe | Zendy; K. Neuber | Zendy

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A multicellular systems biology model predicts epidermal morphology, kinetics and Ca2+ flow

Author(s) -

Niels Grabe,

K. Neuber

Publication year - 2005

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bti585

Subject(s) - epidermis (zoology) , multicellular organism , biology , systems biology , epithelial tissue , microbiology and biotechnology , computer science , computational biology , epithelium , anatomy , cell , biochemistry , genetics

Systems biology is currently focused on integrating intracellular networks, although clinically, diseases are largely defined by their histological features. For example, no computational model can simulate today the formation of a horizontally layered epidermis. Since the epidermis is the most complex structured epithelial tissue, systems biology models could yield important insights in epithelial tissue, in which most of all human cancers arise.

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