Local modeling of global interactome networks | Zendy

Denise Scholtens | Zendy; Marc Vidal | Zendy; Robert Gentleman | Zendy

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Local modeling of global interactome networks

Author(s) -

Denise Scholtens,

Marc Vidal,

Robert Gentleman

Publication year - 2005

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bti567

Subject(s) - interactome , computer science , bioconductor , systems biology , annotation , computational biology , interpretability , data mining , theoretical computer science , biology , artificial intelligence , gene , genetics

Systems biology requires accurate models of protein complexes, including physical interactions that assemble and regulate these molecular machines. Yeast two-hybrid (Y2H) and affinity-purification/mass-spectrometry (AP-MS) technologies measure different protein-protein relationships, and issues of completeness, sensitivity and specificity fuel debate over which is best for high-throughput 'interactome' data collection. Static graphs currently used to model Y2H and AP-MS data neglect dynamic and spatial aspects of macromolecular complexes and pleiotropic protein function.

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