IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content | Zendy

Zsuzsanna Dosztányi | Zendy; Veronika Csizmók | Zendy; Péter Tompa | Zendy; István Simon | Zendy

Open Access

IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content

Author(s) -

Zsuzsanna Dosztányi,

Veronika Csizmók,

Péter Tompa,

István Simon

Publication year - 2005

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bti541

Subject(s) - pairwise comparison , web server , computer science , energy (signal processing) , amino acid residue , computational biology , data mining , chemistry , biology , biochemistry , artificial intelligence , peptide sequence , world wide web , mathematics , the internet , statistics , gene

Intrinsically unstructured/disordered proteins and domains (IUPs) lack a well-defined three-dimensional structure under native conditions. The IUPred server presents a novel algorithm for predicting such regions from amino acid sequences by estimating their total pairwise interresidue interaction energy, based on the assumption that IUP sequences do not fold due to their inability to form sufficient stabilizing interresidue interactions. Optional to the prediction are built-in parameter sets optimized for predicting short or long disordered regions and structured domains.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research