Statistics of protein library construction | Zendy

Andrew E. Firth | Zendy; Wayne M. Patrick | Zendy

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Statistics of protein library construction

Author(s) -

Andrew E. Firth,

Wayne M. Patrick

Publication year - 2005

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bti516

Subject(s) - shuffling , computer science , code (set theory) , dna shuffling , source code , sampling (signal processing) , interface (matter) , encoding (memory) , information retrieval , statistics , data mining , programming language , biology , mathematics , artificial intelligence , genetics , gene , set (abstract data type) , directed evolution , filter (signal processing) , bubble , maximum bubble pressure method , parallel computing , mutant , computer vision

We have investigated the statistics associated with constructing and sampling large protein-encoding libraries. Using fairly simple statistics we have written algorithms for estimating the diversity in libraries generated by the most commonly used protocols, including error-prone PCR, DNA shuffling, StEP PCR, oligonucleotide-directed randomization, MAX randomization, synthetic shuffling, DHR, ADO and SISDC.

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