Open AccessSECISDesign: a server to design SECIS-elements within the coding sequence
Author(s) -
Anke Busch,
Sebastian Will,
Rolf Backofen
Publication year - 2005
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/bti507
Subject(s) - coding (social sciences) , computer science , sequence (biology) , computational biology , biology , genetics , mathematics , statistics
SECISDesign is a server for the design of SECIS-elements and arbitrary RNA-elements within the coding sequence of an mRNA. The element has to satisfy both structure and sequence constraints. At the same time, a certain amino acid similarity to the original protein has to be kept. The designed sequence can be used for recombinant expression of selenoproteins in Escherichia coli.
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