Association mapping and fine mapping with TreeLD | Zendy

Sebastian Zöllner | Zendy; Xiaoquan Wen | Zendy; Jonathan K. Pritchard | Zendy

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Association mapping and fine mapping with TreeLD

Author(s) -

Sebastian Zöllner,

Xiaoquan Wen,

Jonathan K. Pritchard

Publication year - 2005

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bti453

Subject(s) - association (psychology) , software , computer science , association mapping , trait , quantitative trait locus , genetic association , biology , computational biology , artificial intelligence , data mining , genetics , single nucleotide polymorphism , programming language , genotype , psychology , gene , psychotherapist

The program package TreeLD implements a unified approach to association mapping and fine mapping of complex trait loci and a novel approach to visualizing association data, based on an inferred ancestry of the sample. Fundamentally, the TreeLD approach is based on the idea that the evidence for association at a particular position is contained in the ancestral tree relating the sampled chromosomes at that position. TreeLD provides an easy-to-use interface and can be applied to case-control, TDT trio and quantitative trait data.

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