Prediction of protein-protein interactions by combining structure and sequence conservation in protein interfaces | Zendy

Ali Selim Aytuna | Zendy; Attila Gürsoy | Zendy; Özlem Keskin | Zendy

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Prediction of protein-protein interactions by combining structure and sequence conservation in protein interfaces

Author(s) -

Ali Selim Aytuna,

Attila Gürsoy,

Özlem Keskin

Publication year - 2005

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bti443

Subject(s) - computer science , protein–protein interaction , in silico , sequence (biology) , protein data bank , protein structure database , protein structure , computational biology , data mining , database , sequence database , biology , genetics , biochemistry , gene

Elucidation of the full network of protein-protein interactions is crucial for understanding of the principles of biological systems and processes. Thus, there is a need for in silico methods for predicting interactions. We present a novel algorithm for automated prediction of protein-protein interactions that employs a unique bottom-up approach combining structure and sequence conservation in protein interfaces.

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