Identification and measurement of neighbor-dependent nucleotide substitution processes | Zendy

Peter F. Arndt | Zendy; Terence Hwa | Zendy

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Identification and measurement of neighbor-dependent nucleotide substitution processes

Author(s) -

Peter F. Arndt,

Terence Hwa

Publication year - 2005

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bti376

Subject(s) - substitution (logic) , identification (biology) , nucleotide , computer science , computational biology , amino acid substitution , genetics , biology , gene , mutation , programming language , botany

Neighbor-dependent substitution processes generated specific pattern of dinucleotide frequencies in the genomes of most organisms. The CpG-methylation-deamination process is, e.g. a prominent process in vertebrates (CpG effect). Such processes, often with unknown mechanistic origins, need to be incorporated into realistic models of nucleotide substitutions.

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