Haplotype reconstruction from SNP fragments by minimum error correction | Zendy

RuiSheng Wang | Zendy; L.-Y. Wu | Zendy; Ziyi Li | Zendy; X.-S. Zhang | Zendy

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Haplotype reconstruction from SNP fragments by minimum error correction

Author(s) -

RuiSheng Wang,

L.-Y. Wu,

Ziyi Li,

X.-S. Zhang

Publication year - 2005

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bti352

Subject(s) - haplotype , snp , single nucleotide polymorphism , algorithm , computer science , genome , genetics , genetic algorithm , computational biology , genotype , biology , machine learning , gene

Haplotype reconstruction based on aligned single nucleotide polymorphism (SNP) fragments is to infer a pair of haplotypes from localized polymorphism data gathered through short genome fragment assembly. An important computational model of this problem is the minimum error correction (MEC) model, which has been mentioned in several literatures. The model retrieves a pair of haplotypes by correcting minimum number of SNPs in given genome fragments coming from an individual's DNA.

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