Evaluation of the gene-specific dye bias in cDNA microarray experiments | Zendy

MarieLaure MartinMagniette | Zendy; Julie Aubert | Zendy; Éric Cabannes | Zendy; J.-J. Daudin | Zendy

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Evaluation of the gene-specific dye bias in cDNA microarray experiments

Author(s) -

MarieLaure MartinMagniette,

Julie Aubert,

Éric Cabannes,

J.-J. Daudin

Publication year - 2005

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bti302

Subject(s) - complementary dna , microarray , computational biology , dna microarray , gene , computer science , microarray analysis techniques , biology , genetics , gene expression

In cDNA microarray experiments all samples are labeled with either Cy3 or Cy5. Systematic and gene-specific dye bias effects have been observed in dual-color experiments. In contrast to systematic effects which can be corrected by a normalization method, the gene-specific dye bias is not completely suppressed and may alter the conclusions about the differentially expressed genes.

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