Selecton: a server for detecting evolutionary forces at a single amino-acid site | Zendy

Adi DoronFaigenboim | Zendy; A. Stern | Zendy; Itay Mayrose | Zendy; Eran Bacharach | Zendy; Tal Pupko | Zendy

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Selecton: a server for detecting evolutionary forces at a single amino-acid site

Author(s) -

Adi DoronFaigenboim,

A. Stern,

Itay Mayrose,

Eran Bacharach,

Tal Pupko

Publication year - 2005

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bti259

Subject(s) - web server , web site , selection (genetic algorithm) , computer science , set (abstract data type) , negative selection , sequence (biology) , identification (biology) , computational biology , darwinism , artificial intelligence , biology , the internet , evolutionary biology , genetics , world wide web , gene , ecology , programming language , genome

We present an algorithmic tool for the identification of biologically significant amino acids in proteins of known three dimensional structure. We estimate the degree of purifying selection and positive Darwinian selection at each site and project these estimates onto the molecular surface of the protein. Thus, patches of functional residues (undergoing either positive or purifying selection), which may be discontinuous in the linear sequence, are revealed. We test for the statistical significance of the site-specific scores in order to obtain reliable and valid estimates.

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