Investigating metabolite essentiality through genome-scale analysis of Escherichia coli production capabilities | Zendy

Marcin Imieliński | Zendy; Călin Belta | Zendy; Ádám Halász | Zendy; Harvey Rubin | Zendy

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Investigating metabolite essentiality through genome-scale analysis of Escherichia coli production capabilities

Author(s) -

Marcin Imieliński,

Călin Belta,

Ádám Halász,

Harvey Rubin

Publication year - 2005

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bti245

Subject(s) - escherichia coli , metabolite , computational biology , scale (ratio) , genome , production (economics) , biology , computer science , genetics , biochemistry , gene , geography , macroeconomics , economics , cartography

A phenotype mechanism is classically derived through the study of a set of mutants and comparison of their biochemical capabilities. One method of comparing mutant capabilities is to characterize producible and knocked out metabolites. However such an effect is difficult to manually assess, especially for a large biochemical network and a complex media. Current algorithmic approaches towards analyzing metabolic networks either do not address this specific property or are computationally infeasible on the genome-scale.

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