Open AccessStructural drift: a possible path to protein fold change
Author(s) -
Sanjeev Krishna,
Nick V. Grishin
Publication year - 2004
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/bti227
Subject(s) - fold (higher order function) , path (computing) , computer science , computational biology , biology , programming language
Along with their mutating sequences, protein structures change in time. Analyzing a formate dehydrogenase domain that is evolutionarily related to ferredoxin, but simultaneously contains all the structural elements of a beta-Grasp fold, we illustrate here a mechanism termed as structural drift, by which changes to a protein fold can occur.
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