TargetFinder: a software for antisense oligonucleotide target site selection based on MAST and secondary structures of target mRNA | Zendy

Xiaochen Bo | Zendy; Shengjun Wang | Zendy

Open Access

TargetFinder: a software for antisense oligonucleotide target site selection based on MAST and secondary structures of target mRNA

Author(s) -

Xiaochen Bo,

Shengjun Wang

Publication year - 2004

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bti211

Subject(s) - messenger rna , oligonucleotide , software , selection (genetic algorithm) , computational biology , mast (botany) , computer science , biology , mast cell , genetics , gene , operating system , artificial intelligence , immunology

TargetFinder is a PC/Windows program for interactive effective antisense oligonucleotide (AO) selection based on mRNA accessible site tagging (MAST) and secondary structures of target mRNA. To make MAST result intuitive, both the alignment result and tag frequency profile is illustrated. As theoretical reference, secondary structure and single strand probability profile of target mRNA is also represented. All of these sequences and profiles are displayed in aligned mode, which facilitates identification of the accessible sites in target mRNA. Graphical, user-friendly interface makes TargetFinder a useful tool in AO target site selection.

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