Open AccessEvidence for the regulation of alternative splicing via complementary DNA sequence repeats
Author(s) -
Yun Lian,
Harold R. Garner
Publication year - 2005
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/bti180
Subject(s) - rna splicing , intron , alternative splicing , exon , tandem repeat , genetics , biology , exonic splicing enhancer , direct repeat , gene , computational biology , genome , rna
While the mechanism for regulating alternative splicing is poorly understood, secondary structure has been shown to be integral to this process. Due to their propensity for forming complementary hairpin loops and their elevated mutation rates, tandem repeated sequences have the potential to influence splicing regulation.
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