AUG codons at the beginning of protein coding sequences are frequent in eukaryotic mRNAs with a suboptimal start codon context | Zendy

А. В. Кочетов | Zendy

Open Access

AUG codons at the beginning of protein coding sequences are frequent in eukaryotic mRNAs with a suboptimal start codon context

Author(s) -

А. В. Кочетов

Publication year - 2004

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bti136

Subject(s) - start codon , codon usage bias , biology , stop codon , translation (biology) , context (archaeology) , genetics , coding region , eukaryotic translation , open reading frame , computational biology , messenger rna , gene , genome , peptide sequence , paleontology

The translation start site plays an important role in the control of translation efficiency of eukaryotic mRNAs. However, mRNAs with a suboptimal context of start AUG codon are relatively abundant. It is likely that at least some mRNAs with suboptimal start codon context contain the other signals providing additional information for efficient AUG recognition.

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