Open AccessDNA assembly with gaps (Dawg): simulating sequence evolution
Author(s) -
Reed A. Cartwright
Publication year - 2005
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/bti1200
Subject(s) - indel , biological data , sequence (biology) , phylogenetic tree , algorithm , computer science , multiple sequence alignment , bootstrapping (finance) , indel mutation , parametric statistics , sequence alignment , biology , mathematics , genetics , statistics , gene , genotype , single nucleotide polymorphism , peptide sequence , econometrics
Relationships amongst taxa are inferred from biological data using phylogenetic methods and procedures. Very few known phylogenies exist against which to test the accuracy of our inferences. Therefore, in the absence of biological data, simulated data must be used to test the accuracy of methods which produce these inferences. Researchers have limited or non-existent options for simulations useful for studying the impact of insertions, deletions, and alignments on phylogenetic accuracy.
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