Identifying differentially expressed genes from microarray experiments via statistic synthesis
Author(s) -
Jean Yang,
Yuanyuan Xiao,
Mark R. Segal
Publication year - 2004
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/bti108
Subject(s) - statistic , microarray , computational biology , gene , microarray analysis techniques , microarray databases , biology , computer science , genetics , gene expression , statistics , mathematics
A common objective of microarray experiments is the detection of differential gene expression between samples obtained under different conditions. The task of identifying differentially expressed genes consists of two aspects: ranking and selection. Numerous statistics have been proposed to rank genes in order of evidence for differential expression. However, no one statistic is universally optimal and there is seldom any basis or guidance that can direct toward a particular statistic of choice.
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