Open AccessComputing the P-value of the information content from an alignment of multiple sequences
Author(s) -
Niranjan Nagarajan,
Neil Jones,
Uri Keich
Publication year - 2005
Publication title -
computer applications in the biosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1460-2059
pISSN - 0266-7061
DOI - 10.1093/bioinformatics/bti1044
Subject(s) - value (mathematics) , computer science , content (measure theory) , computational biology , mathematics , biology , machine learning , mathematical analysis
The efficient and accurate computation of P-values is an essential requirement for motif-finding and alignment tools. We show that the approximation algorithms used in two popular motif-finding programs, MEME and Consensus, can fail to accurately compute the P-value.
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