hp-DPI: Helicobacter pylori Database of Protein Interactomes—embracing experimental and inferred interactions
Author(s) -
ChungYen Lin,
Chia-Ling Chen,
Chi-Shiang Cho,
Liming Wang,
ChiaMing Chang,
PaoYang Chen,
Chen-Zen Lo,
Chao A. Hsiung
Publication year - 2004
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/bti101
Subject(s) - protein–protein interaction , genbank , helicobacter pylori , kegg , annotation , computational biology , visualization , biology , computer science , database , genetics , data mining , gene ontology , gene , gene expression
We implemented a statistical model into our protein interaction database for validation of two-hybrid assays of Helicobacter pylori, and prediction of putative protein interactions not yet discovered experimentally. To present the enormous amount of experimental and inferred protein interaction networking maps, the H.pylori Database of Protein Interactomes (hp-DPI) is developed with a succinct yet comprehensive visualization tool integrated with annotation from Genbank, GO, and KEGG. hp-DPI is first built with, but not limited to, H.pylori protein interactions and is expected to naturally include other organisms' protein interacting relationships in the future.
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