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Inferring quantitative models of regulatory networks from expression data
Author(s) -
Iftach Nachman,
Aviv Regev,
Nir Friedman
Publication year - 2004
Publication title -
bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.599
H-Index - 390
eISSN - 1367-4811
pISSN - 1367-4803
DOI - 10.1093/bioinformatics/bth941
Subject(s) - computer science , probabilistic logic , gene regulatory network , expression (computer science) , key (lock) , regulator , data mining , artificial intelligence , machine learning , computational biology , gene expression , biology , gene , genetics , programming language , computer security
Genetic networks regulate key processes in living cells. Various methods have been suggested to reconstruct network architecture from gene expression data. However, most approaches are based on qualitative models that provide only rough approximations of the underlying events, and lack the quantitative aspects that are critical for understanding the proper function of biomolecular systems.

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