High density linkage disequilibrium mapping using models of haplotype block variation | Zendy

Gideon Greenspan | Zendy; Dan Geiger | Zendy

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High density linkage disequilibrium mapping using models of haplotype block variation

Author(s) -

Gideon Greenspan,

Dan Geiger

Publication year - 2004

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bth907

Subject(s) - linkage disequilibrium , haplotype , tag snp , single nucleotide polymorphism , linkage (software) , computational biology , haplotype estimation , genetics , association mapping , biology , genetic association , block (permutation group theory) , computer science , data mining , genotype , gene , mathematics , geometry

The presence of millions of single nucleotide polymorphisms (SNPs) in the human genome has spurred interest in genetic mapping methods based on linkage disequilibrium. The recently discovered haplotype block structure of human variation promises to improve the effectiveness of these methods. A key difficulty for mapping techniques is the cost involved in separately identifying the haplotypes on each of an individual's chromosomes.

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