Filtering of Ineffective siRNAs and Improved siRNA Design Tool | Zendy

SiuMing Yiu | Zendy; Prudence W. H. Wong | Zendy; TakWah Lam | Zendy; Yuen-chi Mui | Zendy; H Kung | Zendy; Marie C.M. Lin | Zendy; Yuen-Ting Cheung | Zendy

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Filtering of Ineffective siRNAs and Improved siRNA Design Tool

Author(s) -

SiuMing Yiu,

Prudence W. H. Wong,

TakWah Lam,

Yuen-chi Mui,

H Kung,

Marie C.M. Lin,

Yuen-Ting Cheung

Publication year - 2004

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bth498

Subject(s) - small interfering rna , computer science , computational biology , biology , rna , genetics , gene

Short interfering RNAs (siRNAs) can be used to suppress gene expression and possess many potential applications in therapy, but how to design an effective siRNA is still not clear. Based on the MPI (Max-Planck-Institute) basic principles, a number of siRNA design tools have been developed recently. The set of candidates reported by these tools is usually large and often contains ineffective siRNAs. In view of this, we initiate the study of filtering ineffective siRNAs.

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