DIVAA: analysis of amino acid diversity in multiple aligned protein sequences | Zendy

Diane J. Rodi | Zendy; Suneeta Mandava | Zendy; Lee Makowski | Zendy

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DIVAA: analysis of amino acid diversity in multiple aligned protein sequences

Author(s) -

Diane J. Rodi,

Suneeta Mandava,

Lee Makowski

Publication year - 2004

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bth432

Subject(s) - hypervariable region , computational biology , functional diversity , biology , conserved sequence , amino acid , sequence (biology) , multiple sequence alignment , sequence analysis , homogeneous , peptide sequence , sequence motif , sequence alignment , sequence logo , consensus sequence , evolutionary biology , genetics , ecology , mathematics , combinatorics , gene

Multiple alignments of proteins are an effective way of identifying conserved amino acids that provide clues to functional relationships among proteins. Quantitation of the abundances of amino acids found at each position in a sequence motif can provide a basis for understanding the structural and functional constraints at each point. Distribution of information across a motif has been used previously, but the non-intuitive nature of the analysis has limited its impact.

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