GeneNetwork: an interactive tool for reconstruction of genetic networks using microarray data | Zendy

Chia-Chin Wu | Zendy; HsuanCheng Huang | Zendy; HsuehFen Juan | Zendy; ShuiTein Chen | Zendy

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GeneNetwork: an interactive tool for reconstruction of genetic networks using microarray data

Author(s) -

Chia-Chin Wu,

HsuanCheng Huang,

HsuehFen Juan,

ShuiTein Chen

Publication year - 2004

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bth428

Subject(s) - computer science , data mining , microarray analysis techniques , genetic data , microarray databases , software , computational biology , biology , programming language , genetics , gene , gene expression , population , demography , sociology

Inferring genetic network architecture from time series data generated from high-throughput experimental technologies, such as cDNA microarray, can help us to understand the system behavior of living organisms. We have developed an interactive tool, GeneNetwork, which provides four reverse engineering models and three data interpolation approaches to infer relationships between genes. GeneNetwork enables a user to readily reconstruct genetic networks based on microarray data without having intimate knowledge of the mathematical models. A simple graphical user interface enables rapid, intuitive mapping and analysis of the reconstructed network allowing biologists to explore gene relationships at the system level.

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