An optimized algorithm for flux estimation from isotopomer distribution in glucose metabolites | Zendy

Vitaly A. Selivanov | Zendy; Joaquim Puigjaner | Zendy; Antonio Sillero | Zendy; Josep J. Centelles | Zendy; Antonio RamosMontoya | Zendy; Paul W. N. Lee | Zendy; Marta Cascante | Zendy

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An optimized algorithm for flux estimation from isotopomer distribution in glucose metabolites

Author(s) -

Vitaly A. Selivanov,

Joaquim Puigjaner,

Antonio Sillero,

Josep J. Centelles,

Antonio RamosMontoya,

Paul W. N. Lee,

Marta Cascante

Publication year - 2004

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bth412

Subject(s) - isotopomers , distribution (mathematics) , algorithm , flux (metallurgy) , estimation , computer science , chemistry , mathematics , engineering , mathematical analysis , organic chemistry , molecule , systems engineering

Analysis of the conversion of (13)C glucose within the metabolic network allows the evaluation of the biochemical fluxes in interconnecting metabolic pathways. Such analyses require solving hundreds of equations with respect to individual isotopomer concentrations, and this assumes applying special software even for constructing the equations. The algorithm, proposed by others could be improved.

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