DNA structure constraint is probably a fundamental factor inducing CpG deficiency in bacteria | Zendy

Yong Wang | Zendy; Frederick C. Leung | Zendy

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DNA structure constraint is probably a fundamental factor inducing CpG deficiency in bacteria

Author(s) -

Yong Wang,

Frederick C. Leung

Publication year - 2004

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bth393

Subject(s) - cpg site , genome , biology , dna , context (archaeology) , dna methylation , genetics , gc content , bacterial genome size , constraint (computer aided design) , differentially methylated regions , dna sequencing , computational biology , gene , mathematics , paleontology , gene expression , geometry

It has been speculated that CpG dinucleotide deficiency in genomes is a consequence of DNA methylation. However, this hypothesis does not adequately explain CpG deficiency in bacteria. The hypothesis based on DNA structure constraint as an alternative explanation was therefore examined.

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