Accuracy improvement for identifying translation initiation sites in microbial genomes | Zendy

Huaiqiu Zhu | Zendy; Gangqing Hu | Zendy; Zhengqing Ouyang | Zendy; Jin Wang | Zendy; Zhen-Su She | Zendy

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Accuracy improvement for identifying translation initiation sites in microbial genomes

Author(s) -

Huaiqiu Zhu,

Gangqing Hu,

Zhengqing Ouyang,

Jin Wang,

Zhen-Su She

Publication year - 2004

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bth390

Subject(s) - orfs , gene , computational biology , open reading frame , translation (biology) , computer science , set (abstract data type) , gene prediction , genetics , genome , sequence (biology) , identification (biology) , eukaryotic translation , biology , messenger rna , peptide sequence , botany , programming language

At present the computational gene identification methods in microbial genomes have a high prediction accuracy of verified translation termination site (3' end), but a much lower accuracy of the translation initiation site (TIS, 5' end). The latter is important to the analysis and the understanding of the putative protein of a gene and the regulatory machinery of the translation. Improving the accuracy of prediction of TIS is one of the remaining open problems.

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