Differences in gene expression between B-cell chronic lymphocytic leukemia and normal B cells: a meta-analysis of three microarray studies | Zendy

J. Wang | Zendy; Kevin R. Coombes | Zendy; W. Edward Highsmith | Zendy; M Keating | Zendy; Lynne V. Abruzzo | Zendy

Open Access

Differences in gene expression between B-cell chronic lymphocytic leukemia and normal B cells: a meta-analysis of three microarray studies

Author(s) -

J. Wang,

Kevin R. Coombes,

W. Edward Highsmith,

M Keating,

Lynne V. Abruzzo

Publication year - 2004

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bth381

Subject(s) - chronic lymphocytic leukemia , microarray analysis techniques , microarray , b cell , gene expression profiling , gene , gene expression , biology , leukemia , microbiology and biotechnology , computational biology , cancer research , genetics , antibody

A major focus of current cancer research is to identify genes that can be used as markers for prognosis and diagnosis, and as targets for therapy. Microarray technology has been applied extensively for this purpose, even though it has been reported that the agreement between microarray platforms is poor. A critical question is: how can we best combine the measurements of matched genes across microarray platforms to develop diagnostic and prognostic tools related to the underlying biology?

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