The UniMarker (UM) method for synteny mapping of large genomes | Zendy

BenYang Liao | Zendy; Yu-Jung Chang | Zendy; Jan-Ming Ho | Zendy; MingJing Hwang | Zendy

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The UniMarker (UM) method for synteny mapping of large genomes

Author(s) -

BenYang Liao,

Yu-Jung Chang,

Jan-Ming Ho,

MingJing Hwang

Publication year - 2004

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bth380

Subject(s) - synteny , ensembl , genome , comparative genomics , computational biology , sequence (biology) , genomics , biology , human genome , orthologous gene , reference genome , genetics , gene

Synteny mapping, or detecting regions that are orthologous between two genomes, is a key step in studies of comparative genomics. For completely sequenced genomes, this is increasingly accomplished by whole-genome sequence alignment. However, such methods are computationally expensive, especially for large genomes, and require rather complicated post-processing procedures to filter out non-orthologous sequence matches.

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