Evidence that microRNA precursors, unlike other non-coding RNAs, have lower folding free energies than random sequences | Zendy

Eric Bonnet | Zendy; J. Wuyts | Zendy; Pierre Rouzé | Zendy; Yves Van de Peer | Zendy

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Evidence that microRNA precursors, unlike other non-coding RNAs, have lower folding free energies than random sequences

Author(s) -

Eric Bonnet,

J. Wuyts,

Pierre Rouzé,

Yves Van de Peer

Publication year - 2004

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bth374

Subject(s) - nucleic acid secondary structure , computational biology , protein secondary structure , ribosomal rna , rna , biology , shuffling , folding (dsp implementation) , microrna , small nucleolar rna , nucleic acid structure , genetics , computer science , non coding rna , gene , biochemistry , electrical engineering , engineering , programming language

Most non-coding RNAs are characterized by a specific secondary and tertiary structure that determines their function. Here, we investigate the folding energy of the secondary structure of non-coding RNA sequences, such as microRNA precursors, transfer RNAs and ribosomal RNAs in several eukaryotic taxa. Statistical biases are assessed by a randomization test, in which the predicted minimum free energy of folding is compared with values obtained for structures inferred from randomly shuffling the original sequences.

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