Breakpoint identification and smoothing of array comparative genomic hybridization data | Zendy

Kees H. de Jong | Zendy; Elena Marchiori | Zendy; Gerrit A. Meijer | Zendy; Aad van der Vaart | Zendy; Bauke Ylstra | Zendy

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Breakpoint identification and smoothing of array comparative genomic hybridization data

Author(s) -

Kees H. de Jong,

Elena Marchiori,

Gerrit A. Meijer,

Aad van der Vaart,

Bauke Ylstra

Publication year - 2004

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bth355

Subject(s) - comparative genomic hybridization , breakpoint , identification (biology) , smoothing , computational biology , computer science , genetics , biology , genome , gene , chromosome , botany , computer vision

We describe a tool, called aCGH-Smooth, for the automated identification of breakpoints and smoothing of microarray comparative genomic hybridization (array CGH) data. aCGH-Smooth is written in visual C++, has a user-friendly interface including a visualization of the results and user-defined parameters adapting the performance of data smoothing and breakpoint recognition. aCGH-Smooth can handle array-CGH data generated by all array-CGH platforms: BAC, PAC, cosmid, cDNA and oligo CGH arrays. The tool has been successfully applied to real-life data.

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