Sequence patterns derived from the automated prediction of functional residues in structurally-aligned homologous protein families | Zendy

Ricardo Núñez Miguel | Zendy

Open Access

Sequence patterns derived from the automated prediction of functional residues in structurally-aligned homologous protein families

Author(s) -

Ricardo Núñez Miguel

Publication year - 2004

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bth255

Subject(s) - protein superfamily , sequence (biology) , function (biology) , computational biology , sequence alignment , structural classification of proteins database , sequence database , biology , conserved sequence , protein family , protein sequencing , sequence analysis , peptide sequence , protein structure , computer science , genetics , biochemistry , gene

Most proteins have evolved to perform specific functions that are dependent on the adoption of well-defined three-dimensional (3D) structures. Specific patterns of conserved residues in amino acid sequences of divergently evolved proteins are frequently observed; these may reflect evolutionary restraints arising both from the need to maintain tertiary structure and the requirement to conserve residues more directly involved in function. Databases of such sequence patterns are valuable in identifying distant homologues, in predicting function and in the study of evolution.

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