A novel method for estimating ancestral amino acid composition and its application to proteins of the Last Universal Ancestor | Zendy

Dawn J. Brooks | Zendy; Jacques R. Fresco | Zendy; Mona Singh | Zendy

Open Access

A novel method for estimating ancestral amino acid composition and its application to proteins of the Last Universal Ancestor

Author(s) -

Dawn J. Brooks,

Jacques R. Fresco,

Mona Singh

Publication year - 2004

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bth235

Subject(s) - extant taxon , amino acid , composition (language) , protein evolution , thermophile , set (abstract data type) , biology , ancestor , computational biology , evolutionary biology , amino acid residue , gene , biochemistry , computer science , peptide sequence , geography , programming language , enzyme , philosophy , linguistics , archaeology

Knowledge of how proteomic amino acid composition has changed over time is important for constructing realistic models of protein evolution and increasing our understanding of molecular evolutionary history. The proteomic amino acid composition of the Last Universal Ancestor (LUA) of life is of particular interest, since that might provide insight into the early evolution of proteins and the nature of the LUA itself.

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