Alignment of RNA base pairing probability matrices | Zendy

Ivo L. Hofacker | Zendy; Stephan Wolf | Zendy; Peter F. Stadler | Zendy

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Alignment of RNA base pairing probability matrices

Author(s) -

Ivo L. Hofacker,

Stephan Wolf,

Peter F. Stadler

Publication year - 2004

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bth229

Subject(s) - pairing , base (topology) , computer science , rna , base pair , computational biology , mathematics , genetics , biology , dna , physics , gene , mathematical analysis , superconductivity , quantum mechanics

Many classes of functional RNA molecules are characterized by highly conserved secondary structures but little detectable sequence similarity. Reliable multiple alignments can therefore be constructed only when the shared structural features are taken into account. Since multiple alignments are used as input for many subsequent methods of data analysis, structure-based alignments are an indispensable necessity in RNA bioinformatics.

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