Pathway Miner: extracting gene association networks from molecular pathways for predicting the biological significance of gene expression microarray data | Zendy

Ritu Pandey | Zendy; Raghavendra K. Guru | Zendy; David W. Mount | Zendy

Open Access

Pathway Miner: extracting gene association networks from molecular pathways for predicting the biological significance of gene expression microarray data

Author(s) -

Ritu Pandey,

Raghavendra K. Guru,

David W. Mount

Publication year - 2004

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bth215

Subject(s) - biological pathway , gene , computational biology , context (archaeology) , biology , dna microarray , gene regulatory network , gene expression profiling , gene expression , genetics , paleontology

We have developed a web-based system (Pathway Miner) for visualizing gene expression profiles in the context of biological pathways. Pathway Miner catalogs genes based on their role in metabolic, cellular and regulatory pathways. A Fisher exact test is provided as an option to rank pathways. The genes are mapped onto pathways and gene product association networks are extracted for genes that co-occur in pathways. The networks can be filtered for analysis based on user-selected options.

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