Alu repeat analysis in the complete human genome: trends and variations with respect to genomic composition | Zendy

Deepak Grover | Zendy; Mitali Mukerji | Zendy; Pankaj Bhatnagar | Zendy; Krishnamoorthy Kannan | Zendy; Samir K. Brahmachari | Zendy

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Alu repeat analysis in the complete human genome: trends and variations with respect to genomic composition

Author(s) -

Deepak Grover,

Mitali Mukerji,

Pankaj Bhatnagar,

Krishnamoorthy Kannan,

Samir K. Brahmachari

Publication year - 2004

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/bth005

Subject(s) - alu element , genome , biology , gene density , human genome , intron , genetics , transposable element , gene , genome evolution , retrotransposon , interspersed repeat , chromosome

Transposon-derived Alu repeats are exclusively associated with primate genomes. They have gained considerable importance in the recent times with evidence of their involvement in various aspects of gene regulation, e.g. alternative splicing, nucleosome positioning, CpG methylation, binding sites for transcription factors and hormone receptors, etc. The objective of this study is to investigate the factors that influence the distribution of Alu repeat elements in the human genome. Such analysis is expected to yield insights into various aspects of gene regulation in primates.

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