Variance-stabilizing transformations for two-color microarrays | Zendy

Blythe Durbin | Zendy; David M. Rocke | Zendy

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Variance-stabilizing transformations for two-color microarrays

Author(s) -

Blythe Durbin,

David M. Rocke

Publication year - 2004

Publication title -

bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.599

H-Index - 390

eISSN - 1367-4811

pISSN - 1367-4803

DOI - 10.1093/bioinformatics/btg464

Subject(s) - variance (accounting) , transformation (genetics) , constant (computer programming) , analysis of variance , mathematics , computer science , differential (mechanical device) , control (management) , statistics , algorithm , artificial intelligence , biology , gene , business , programming language , engineering , aerospace engineering , biochemistry , accounting

Authors of several recent papers have independently introduced a family of transformations (the generalized-log family), which stabilizes the variance of microarray data up to the first order. However, for data from two-color arrays, tests for differential expression may require that the variance of the difference of transformed observations be constant, rather than that of the transformed observations themselves.

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